Catenin beta-1

BT-AP07146

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

The antiserum was produced against synthesized peptide derived from human Catenin-beta. AA range:455-504

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants.

Human: P35222; Mouse: Q02248; Rat: Q9WU82;

85497

Human: 1499; Mouse: 12387; Rat: 84353

Catenin beta-1; CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

Cancer; Cardiovascular; Neuroscience; Signal transduction; Stem cells; Epigenetics and nuclear signaling

CTNNB1