Lanosterol 14-alpha demethylase

BT-AP08048

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 210-290

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.

Human: Q16850; Mouse: Q8K0C4; Rat: Q64654;

Human: 1595

Lanosterol 14-alpha demethylase ;LDM;EC 1.14.13.70;CYPLI;Cytochrome P450 51A1;Cytochrome P450-14DM;Cytochrome P45014DM;Cytochrome P450LI;Sterol 14-alpha demethylase

Cancer; Cardiovascular; Metabolism; Signal transduction; Neuroscience

CYP51A1