Growth arrest and DNA damage-inducible protein GADD45 beta

BT-AP09329

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 90-170

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth.

Human: O75293; Mouse: P22339;

Human: 4616

Growth arrest and DNA damage-inducible protein GADD45 beta ;Myeloid differentiation primary response protein MyD118;Negative growth regulatory protein MyD118

Cancer; Cell biology; Epigenetics and nuclear signaling; Immunology; Signal transduction

GADD45B