KH domain-containing, RNA-binding, signal transduction-associated protein 3

BT-AP10676

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from part region of human protein

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

The proline-rich site binds the SH3 domain of the p85 subunit of PI3-kinase.,RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression.,induction:Induced in proteinuric diseases. Down-regulated in immortalized fibroblasts isolated after a proliferative crisis accompanied with massive cell death.,PTM:Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated.,Belongs to the KHDRBS family.,Contains 1 KH domain.,subcellular location:Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.,subunit:Self-associates to form homo-oligomers. Interacts with the splicing regulatory proteins SFRS9, SAFB and YTHDC1. Interacts also with HNRPL and SLM1/KHDRBS2 (By similarity). Interacts with KHDRBS1, RBMX, RBMY1A1 and with p85 subunit of PI3-kinase. Interacts also with SIAH1 which promotes targeting for degradation.,tissue specificity:Ubiquitous with higher expression in testis, skeletal muscle and brain. Expressed in the kidney only in podocytes, the glomerular epithelial cells of the kidney. Strongly expressed after meiosis.,

Human: O75525; Mouse: Q9R226; Rat: Q9JLP1;

Human: 10656

KH domain-containing, RNA-binding, signal transduction-associated protein 3 ;RNA-binding protein T-Star;Sam68-like mammalian protein 2;SLM-2;Sam68-like phosphotyrosine protein

Epigenetics and nuclear signaling

KHDRBS3