Full product name
ATP-sensitive inward rectifier potassium channel 11
Code
BT-AP10704
Host
Rabbit
Isotype
IgG
Size
20ul,50ul,100ul
Clonality
Polyclonal
Immunogen
The antiserum was produced against synthesized peptide derived from human Kir6.2 around the phosphorylation site of Thr224. AA range:190-239
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage
-20°C for 1 year
Background
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced trans
Uniprot accession
Molecular weight
43562
Gene ID
Human: 3767; Mouse: 16514; Rat: 83535
Synonyms
ATP-sensitive inward rectifier potassium channel 11; KCNJ11; ATP-sensitive inward rectifier potassium channel 11; IKATP; Inward rectifier K;+ channel Kir6.2; Potassium channel; inwardly rectifying subfamily J member 11
Research area
Cancer; Cardiovascular; Metabolism; Neuroscience; Signal transduction
Target protein
KCNJ11
