Leptin receptor

BT-AP12168

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized phospho-peptide around the phosphorylation site of human Ob-R (phospho Tyr1141)

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

Human: P48357; Mouse: P48356;

132494

Human: 3953; Mouse: 16847

Leptin receptor; LEPR; DB; OBR; Leptin receptor; LEP-R; HuB219; OB receptor; OB-R; CD antigen CD295

Cancer; Cardiovascular; Metabolism; Signal transduction

LEPR