Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

BT-AP12184

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from human protein . at AA range: 230-310

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Human: P08559; Mouse: P35486; Rat: P26284;

Human: 5160

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial ;EC 1.2.4.1;PDHE1-A type I

Cancer; Metabolism; Signal transduction

PDHA1