Histone acetyltransferase p300

BT-AP12631

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized acetyl-peptide derived from human p300 around the acetylation site of K1558.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for 1 year

This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer.

Histone acetyltransferase p300; EP300; P300; Histone acetyltransferase p300; p300 HAT; E1A-associated protein p300

Cancer; Epigenetics and nuclear signaling; Metabolism; Stem cells

EP300