TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

BT-AP14707

Rabbit

IgG

100ul,50ul,20ul

Polyclonal

Synthesized peptide derived from part region of human protein

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

-20°C for 1 year

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Human: Q8N5C8; Mouse: Q571K4;

Human: 257397

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 ;Mitogen-activated protein kinase kinase kinase 7-interacting protein 3;NF-kappa-B-activating protein 1;TAK1-binding protein 3;TAB-3;TG

Epigenetics and nuclear signaling; Signal transduction; Immunology

TAB3