Code
BT-MCA3461
Host
Mouse
Isotype
Mouse IgG2b
Size
100μL,50μL
Clonality
Monoclonal
Immunogen
Purified recombinant fragment of human RAP1GAP (AA: 412-660) expressed in E. Coli.
Formulation
Purified antibody in PBS with 0.05% sodium azide.
Storage
Store at 4°C short term. Aliquot and store at -20°C long term.
Background
This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins.
Uniprot accession
Molecular weight
73.4kDa
Gene ID
5909
Synonyms
RAPGAP;RAP1GA1;RAP1GAP1;RAP1GAPII
Research area
Signal Transduction
Target protein
RAP1GAP
