CRSP77 Antibody

BT-AP02253

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

The antiserum was produced against synthesized peptide derived from human MED17. AA range:141-190

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. Mediator complex subunit 17 encoded by MED17 is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor- (TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.

Human: Q9NVC6; Mouse: Q8VCD5;

72876

Human: 9440; Mouse: 234959

MED17; ARC77; CRSP6; DRIP77; DRIP80; TRAP80; Mediator of RNA polymerase II transcription subunit 17; Activator-recruited cofactor 77 kDa component; ARC77; Cofactor required for Sp1 transcriptional act

Neuroscience; Endocrine system

MED17