PGI2 synthase Antibody

BT-AP07100

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from the C-terminal region of human PGI2 synthase.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

PTGIS (prostaglandin I2 (prostacyclin) synthase) encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Human: Q16647; Mouse: O35074; Rat: Q62969;

57104

Human: 5740; Mouse: 19223; Rat: 25527

PTGIS; CYP8; CYP8A1; Prostacyclin synthase; Prostaglandin I2 synthase

Immunology

PTGIS