TGIF Antibody

BT-AP08983

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Synthesized peptide derived from the C-terminal region of human TGIF.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

-20°C for one year

The protein encoded by TGIF1 (TGFB induced factor homeobox 1) is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in TGIF1 are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.

Human: Q15583; Mouse: P70284;

43044

Human: 7050; Mouse: 21815

TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1

Neuroscience

TGIF1