beta-Catenin Antibody

BT-AP09791

Rabbit

IgG

20ul,50ul,100ul

Polyclonal

Recombinant Protein of Catenin beta-1

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/ml

PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.

-20°C for one year

The protein encoded by CTNNB1 (catenin beta 1) is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in CTNNB1 are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for CTNNB1.

Human: P35222; Mouse: Q02248; Rat: Q9WU82;

85497

Human: 1499; Mouse: 12387; Rat: 84353

CTNNB1; CTNNB; OK/SW-cl.35; Catenin beta-1; Beta-catenin

Signal Transduction

CTNNB1