Receptor tyrosine-protein kinase erbB-2

BPE368

Sandwich

5*96T,96T,15*96T

7.59 pg/mL

24-1500 pg/mL

Serum, plasma, cell culture supernates

Human

2-8°C

3.5h

Human epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein and belongs to the epidermal growth factor (EGF) receptor family. HER2 protein cannot bind growth factors due to the lacking of ligand binding domain of its own and autoinhibited constitutively. However, HER2 forms a heterodimer with other ligand-bound EGF receptor family members, therefore stabilizes ligand binding and enhances kinase-mediated activation of downstream molecules. HER2 plays a key role in development, cell proliferation and differentiation. HER2 gene has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on.

137910

2064

HER2;MLN19;NEU;NGL

ERBB2

Cancer,Neuroscience,Signal transduction,Tags & cell markers

Her2