Tnf Receptor-Associated Factor 2

E3268Hu

Sandwich

48T,96T

10.28ng/L

20-6000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

55,859

7186

E3 ubiquitin-protein ligase TRAF2;RING-type E3 ubiquitin transferase TRAF2;TNF receptor-associated factor 2;TRAF 2;TRAF2;Tumor necrosis factor type 2 receptor-associated protein 3

TRAF2

Cell Biology

TRAF2