Tnf Receptor-Associated Factor 6

E2253Bo

Sandwich

96T,48T

6.48ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Bovine

2-8ºC

1h 30m

E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Mediates activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c-Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.

61,647

539124

E3 ubiquitin-protein ligase TRAF6;RING-type E3 ubiquitin transferase TRAF6;TNF receptor-associated factor 6;TRAF 6;TRAF6

TRAF6

Cell Biology

TRAF6