Kininogen-1

E3338Hu

Sandwich

48T,96T

9.02nmol/ml

15-4000nmol/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active Peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

71,957

3827

Alpha-2-thiol proteinase inhibitor;Bradykinin;Fitzgerald factor;High molecular weight kininogen;HMWK;Ile-Ser-Bradykinin;Kallidin I;Kallidin II;Kininogen-1;Kininogen-1 heavy chain;Kininogen-1 light chain;KNG 1;KNG1;Low molecular weight growth-promoting factor;Lysyl-bradykinin;T-kinin;Williams-Fitzgerald-Flaujeac factor

KNG1

Cardiovascular

KNG1