Receptor-type tyrosine-protein phosphatase H

E1595Hu

Sandwich

48T,96T

0.28ng/ml

0.5-100ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of activity of Jurkat cells. Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response CEACAM20 (By similarity).

122,353

5794

PTPRH;Receptor-type tyrosine-protein phosphatase H;R-PTP-H;SAP1;SAP-1;Stomach cancer-associated protein tyrosine phosphatase 1;Transmembrane-type protein-tyrosine phosphatase type H

PTPRH

Signal Transduction

PTPRH