Receptor-type tyrosine-protein phosphatase eta

E1601Hu

Sandwich

48T,96T

0.029ng/ml

0.05-30ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Tyrosine phosphatase which dephosphorylates or contributes to the dephosphorylation of CTNND1, FLT3, PDGFRB, MET, RET (variant MEN2A), KDR, LYN, SRC, MAPK1, MAPK3, EGFR, TJP1, OCLN, PIK3R1 and PIK3R2. Plays a role in cell adhesion, migration, proliferation and differentiation. Involved in vascular development. Regulator of macrophage adhesion and spreading. Positively affects cell-matrix adhesion. Positive regulator of platelet activation and thrombosis. Negative regulator of cell proliferation. Negative regulator of PDGF-stimulated cell migration; through dephosphorylation of PDGFR. Positive regulator of endothelial cell survival, as well as of VEGF-induced SRC and AKT activation; through KDR dephosphorylation. Negative regulator of EGFR signaling pathway; through EGFR dephosphorylation. Enhances the barrier function of epithelial junctions during reassembly. Negatively regulates T-cell receptor (TCR) signaling. Upon T-cell TCR activation, it is up-regulated and excluded from the immunological synapses, while upon T-cell-antigen presenting cells (APC) disengagement, it is no longer excluded and can dephosphorylate PLCG1 and LAT to down-regulate prolongation of signaling.

145,941

5795

CD antigen CD148;CD148;Density-enhanced phosphatase 1;DEP1;DEP-1;HPTP eta;HPTPeta;Protein-tyrosine phosphatase eta;Protein-tyrosine phosphatase receptor type J;PTPRJ;Receptor-type tyrosine-protein phosphatase eta;R-PTP-ETA;R-PTP-J;SCC1

PTPRJ

Signal Transduction

PTPRJ