Peroxiredoxin 6

E1635Ra

Sandwich

48T,96T

5.17ng/L

10.23-3000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:15004285). Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides (By similarity). Also has phospholipase activity, can therefore either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity) (PubMed:8999971, PubMed:15004285, PubMed:17652308). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH (By similarity). Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis (By similarity). Exhibits acyl-CoA-dependent lysophospholipid acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (PubMed:26830860). Shows a clear preference for LPC as the lysophospholipid and for palmitoyl CoA as the fatty acyl substrate (By similarity).

24,819

94167

1-Cys peroxiredoxin;1-Cys PRX;Acidic calcium-independent phospholipase A2;aiPLA2;Antioxidant protein 2;Glutathione-dependent peroxiredoxin;LPC acyltransferase 5;LPCAT-5;Lyso-PC acyltransferase 5;Lysophosphatidylcholine acyltransferase 5;Non-selenium glutathione peroxidase;NSGPx;Peroxiredoxin-6;PRDX6;Thiol-specific antioxidant protein

Prdx6

Signal Transduction

PRDX6