DNA replication licensing factor MCM2

E2028Mo

Sandwich

48T,96T

7.55ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division. Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis.

102,078

17216

AA959861;AW476101;BM28;CDCL;CDCL1;DNA replication licensing factor MCM2;MCM2;Mcmd2;Minichromosome maintenance protein 2 homolog;Nuclear protein BM28

Mcm2

Epigenetics and Nuclear Signaling

MCM2