Interleukin 24

E2162Hu

Sandwich

48T,96T

2.56ng/L

5-1500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Interleukin 24 (IL-24) is a protein in the interleukin family, a type of cytokine signaling molecule in the immune system. In humans, this protein is encoded by the IL24 gene. IL-24 is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. IL-24 appears to control cell survival and proliferation by inducing rapid activation of particular transcription factors called STAT1 and STAT3. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells[5] and acts on skin, lung, and reproductive tissues. IL-24 performs important roles in wound healing, arthritis, psoriasis and cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. The gene for IL-24 is located on chromosome 1 in humans.

23,825

11009

C49A;FISP;IL10B;IL-24;Interleukin-24;MDA7;MDA-7;Melanoma differentiation-associated gene 7 protein;MOB5;ST16;Suppression of tumorigenicity 16 protein

IL24

Immunology

IL-24