Neuronal cell adhesion molecule

E2176Ra

Sandwich

48T,96T

9.67ng/L

20-7000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons (By similarity). Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons (PubMed:16039564). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.

133,912

497815

Ankyrin-binding cell adhesion molecule NrCAM;Neuronal cell adhesion molecule;Neuronal surface protein Bravo;Ng-CAM-related;NgCAM-related cell adhesion molecule;NRCAM;Nr-CAM;rBravo

Nrcam

Neuroscience

NRCAM