C-C motif chemokine 8

E2198Bo

Sandwich

48T,96T

7.19ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Bovine

2-8ºC

1h 30m

Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene. CCL8 is a small cytokine belonging to the CC chemokine family. The CCL8 protein is produced as a precursor containing 109 amino acids, which is cleaved to produce mature CCL8 containing 75 amino acids. The gene for CCL8 is encoded by 3 exons and is located within a large cluster of CC chemokines on chromosome 17q11.2 in humans. MCP-2 is chemotactic for and activates many different immune cells, including mast cells, eosinophils and basophils, (that are implicated in allergic responses), and monocytes, T cells, and NK cells that are involved in the inflammatory response. CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.

10,900

281044

C-C motif chemokine 8;CCL8;MCP-2;Monocyte chemoattractant protein 2;Monocyte chemotactic protein 2;SCYA8;Small-inducible cytokine A8

CCL8

Immunology

CCL8