Transcription Factor 7

E3430Hu

Sandwich

48T,96T

0.054ng/ml

0.1-40ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (By similarity). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (By similarity). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes.

41,642

6932

T-cell factor 1;T-cell-specific transcription factor 1;TCF 7;TCF-1;TCF7;TCF-7;Transcription factor 7

TCF7

Epigenetics and Nuclear Signaling

TCF7