Sonic hedgehog protein

E2263Ra

Sandwich

48T,96T

4.48ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Rat

2-8ºC

1h 30m

The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). The dually lipidated sonic hedgehog protein N-product (ShhNp) is a morphogen which is essential for a variety of patterning events during development. Induces ventral cell fate in the neural tube and somites (By similarity). Involved in the patterning of the anterior-posterior axis of the developing limb bud (By similarity). Essential for axon guidance (By similarity). Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). In the absence of SHH, PTCH1 represses the constitutive signaling activity of SMO (By similarity).

47,630

29499

SHH;Shh N-terminal processed signaling domains;Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains;ShhN;ShhNC;ShhNp];Sonic hedgehog protein;Sonic hedgehog protein N-product

Shh

Others

SHH