Ras-related protein Rab-1A

E2417Mo

Sandwich

48T,96T

7.23ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:20639577, PubMed:22854043). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:20639577, PubMed:22854043). RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion (By similarity). Regulates the level of CASR present at the cell membrane (By similarity). Plays a role in cell adhesion and cell migration, via its role in protein trafficking (PubMed:20639577). Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria (By similarity). Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport (PubMed:22854043).

22,678

19324

Gtb;Gtbp;mKIAA3012;Ra;Rab;Rab1;Rab-1;RAB1A;Ras-related protein Rab-1A;Ypt;YPT1-related protein

Rab1A

Signal Transduction

RAB1A