suppressors of cytokine signaling 1

E2496Mo

Sandwich

48T,96T

12.01ng/L

20-7000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (PubMed:15522878). Through binding to JAKs and IFNGR1, inhibits their kinase activity (PubMed:9202125). In vitro, also suppresses Tec protein-tyrosine activity (By similarity). Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF) (PubMed:9202125). Regulates interferon-gamma (IFNG) mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2 (By similarity). SOCS1 appears to be a negative regulator in IGF1R signaling pathway (By similarity).

23,715

12703

Cis;Cish1;JA;JAB;JAK-binding protein;SOC;SOCS-1;SS;SSI-1;STAT-induced STAT inhibitor 1;Suppressor of cytokine signaling 1

Socs1

Immunology; Signal Transduction; Epigenetics and Nuclear Signaling; Stem Cells; Cancer; Metabolism

SOCS-1