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Home > Product > ELISA Kit > Mouse TGF-beta Receptor Type-2, TGFBR2 ELISA Kit

Mouse TGF-beta Receptor Type-2, TGFBR2 ELISA Kit

Mouse TGF-beta Receptor Type-2, TGFBR2 ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 14.66ng/L

Detection range: 30-9000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Mouse

Product Summary

Size: 48T,96T

Sensitivity: 14.66ng/L

Detection range: 30-9000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Mouse

Product overview

Full product name

TGF-beta receptor type-2

Code

E2510Mo

Assay type

Sandwich

Size

48T,96T

Sensitivity

14.66ng/L

Detection range

30-9000ng/L

Sample type

Serum, plasma, cell culture supernates

Species

Mouse

Storage

2-8ºC

Assay time

1h 30m

Background

Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).

UniProt accession

MASS(Da)

67,122

GeneID

21813

Synonyms

1110020H15Rik;DNIIR;RIIDN;Tbet;Tbeta;TbetaRII;TbetaR-II;TBR;TBR-II;TGF-beta receptor type II;TGF-beta receptor type-2;TGF-beta type II receptor;TGFBR2;TGFR-2;Transforming growth factor-beta receptor type II

Gene names

Tgfbr2

Research area

Signal Transduction

Target protein

TGFBR2

Components

Components Quantity
Pre-coated ELISA plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E2510Mo are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
4800ng/L 2.13 2.245 2.212
2.359
2400ng/L 1.536 1.596 1.563
1.656
1200ng/L 1.001 1.083 1.05
1.165
600ng/L 0.771 0.745 0.712
0.719
300ng/L 0.415 0.419 0.387
0.424
0ng/L 0.04 0.033 0
0.026

Precision

We measured random samples of E2510Mo within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 1165.04 85.04 7.3
Intra-Assay 2 18 2480.78 132.84 5.35
Intra-Assay 3 18 521.04 39.4 7.56

Protocols

References

Customer reviews and Q&As

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  • Size

    Code

    Price

  • 48T

    E2510Mo

    $320.00

  • 96T

    E2510Mo

    $458.00

Add to Cart

Lead time: Within two weeks

We are continuously updating our ELISA Kit catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

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