WAP four-disulfide core domain protein 2

E2567Mo

Sandwich

48T,96T

14.22ng/L

30-9000ng/L

Serum, plasma, cell culture supernates

Mouse

2-8ºC

1h 30m

WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene. HE4 is a tumor marker of ovarian cancer, with 80% sensitivity at a cut-off of 150 pmol/L. This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers.[5] The encoded protein is a small secretory protein, which may be involved in sperm maturation.

18,032

67701

1600023A02Rik;HE4;WA;WAP domain-containing protein HE4;WAP four-disulfide core domain protein 2;WAP5;WFDC2

Wfdc2

Tags & Cell Markers

WFDC2