Chromobox protein homolog 3

E2895Hu

Sandwich

48T,96T

2.22ng/L

5-1000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1. Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679).

20,811

11335

CBX3;Chromobox protein homolog 3;HECH;Heterochromatin protein 1 homolog gamma;HP1 gamma;HP1-GAMMA;HP1Hs-gamma;Modifier 2 protein

CBX3

Epigenetics and Nuclear Signaling

CBX3