Aldo-keto reductase family 1 member C3

E3275Hu

Sandwich

48T,96T

8.32ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone (PubMed:10622721, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:9927279). Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH (PubMed:14672942, PubMed:11165022). Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone (PubMed:20036328). Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol (PubMed:15047184, PubMed:20036328, PubMed:10622721, PubMed:11165022, PubMed:10998348, PubMed:19010934). Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) (PubMed:10998348, PubMed:14672942, PubMed:11165022, PubMed:7650035, PubMed:9415401, PubMed:10557352). Displays also retinaldehyde reductase activity toward 9-cis-retinal (PubMed:21851338).

36,853

8644

17-beta-HSD 5;17-beta-hydroxysteroid dehydrogenase type 5;3-alpha-HSD type 2;3-alpha-HSD type II, brain;3-alpha-hydroxysteroid dehydrogenase type 2;AKR1C3;Aldo-keto reductase family 1 member C3;Chlordecone reductase homolog HAKRb;DD3;DD-3;DDX;Dihydrodiol dehydrogenase 3;Dihydrodiol dehydrogenase type I;HA1753;HAKRB;HAKRe;hluPGFS;PGFS;Prostaglandin F Synthase;Testosterone 17-beta-dehydrogenase 5

AKR1C3

Signal Transduction

AKR1C3