AT rich interactive domain containing protein 1A

E3933Hu

Sandwich

48T,96T

6.61ng/L

12.5-800ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

242,045

8289

ARID domain-containing protein 1A;ARID1A;AT-rich interactive domain-containing protein 1A;B120;BAF250;BAF250a;BRG1-associated factor 250;BRG1-associated factor 250a;C1orf4;CSS2;ELD;hELD;hOSA1;MRD14;Osa homolog 1;OSA1;P270;SMARCF1;SWI/SNF complex protein p270;SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1;SWI-like protein

ARID1A

Signal Transduction

ARID1A