E3 SUMO-protein ligase NSE2

E3970Hu

Sandwich

48T,96T

10.12ng/L

20-3800ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination (PubMed:16055714, PubMed:16810316). Is not be required for the stability of the complex (PubMed:16055714, PubMed:16810316). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks (PubMed:16055714, PubMed:16810316). The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs) (PubMed:17589526). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2 (PubMed:16055714, PubMed:16810316, PubMed:17589526, PubMed:31400850). Required for recruitment of telomeres to PML nuclear bodies (PubMed:17589526). SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines (PubMed:17589526). Required for sister chromatid cohesion during prometaphase and mitotic progression (PubMed:19502785).

27,932

286053

C8orf36;E3 SUMO-protein ligase NSE2;E3 SUMO-protein transferase NSE2;hMMS21;MMS21;MMS21 homolog;Non-SMC element 2 homolog;Non-structural maintenance of chromosomes element 2 homolog;NSE2;NSMCE2;ZMIZ7

NSMCE2

Epigenetics and Nuclear Signaling

NSMCE2