Interferon-induced protein with tetratricopeptide repeats 2

E3973Hu

Sandwich

48T,96T

2.58ng/L

5-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

54,632

3433

cig42;G10P2;GARG-39;IFI54;IFI-54;IFI-54K;IFIT2;IFIT-2;Interferon-induced 54 kDa protein;Interferon-induced protein with tetratricopeptide repeats 2;ISG54;ISG-54;ISG-54 K;ISG-54K;P54

IFIT2

Immunology

IFIT2