Nicotinamide Phosphoribosyltransferase

E3660Hu

Sandwich

48T,96T

0.115ng/ml

0.2-60ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-ARNTL/BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity).

55,521

10135

NAmPRTase;Nampt;Nicotinamide phosphoribosyltransferase;Pre-B cell-enhancing factor;Pre-B-cell colony-enhancing factor 1;VISFATIN

VISFATIN

Metabolism

VISFATIN