Protein S100-B

E3669Hu

Sandwich

48T,96T

0.22ng/L

0.5-300ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.

10,713

6285

Protein S100-B;S100 calcium-binding protein B;S-100 protein beta chain;S-100 protein subunit beta;S100B

S100B

Signal Transduction

S100B