Aminoacyl tRNA Synthase complex-interacting multifunctional protein 1

E4939Hu

Sandwich

48T,96T

7.39ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Non-catalytic component of the multisynthase complex. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase (PubMed:10358004). Binds tRNA. Possesses inflammatory cytokine activity (PubMed:11306575). Negatively regulates TGF-beta signaling through stabilization of SMURF2 by binding to SMURF2 and inhibiting its SMAD7-mediated degradation (By similarity). Involved in glucose homeostasis through induction of glucagon secretion at low glucose levels (By similarity). Promotes dermal fibroblast proliferation and wound repair (PubMed:16472771). Regulates KDELR1-mediated retention of HSP90B1/gp96 in the endoplasmic reticulum (By similarity). Plays a role in angiogenesis by inducing endothelial cell migration at low concentrations and endothelian cell apoptosis at high concentrations (PubMed:12237313). Induces maturation of dendritic cells and monocyte cell adhesion (PubMed:11818442). Modulates endothelial cell responses by degrading HIF-1A through interaction with PSMA7 (PubMed:19362550).

34,353

9255

Aminoacyl tRNA Synthase complex-interacting multifunctional protein 1;EMAP2;EMAP-2;EMAPII;EMAP-II;Endothelial monocyte-activating polypeptide 2;Endothelial monocyte-activating polypeptide II;HLD3;Multisynthase complex auxiliary component p43;p43;SCYE1;Small inducible cytokine subfamily E member 1]

AIMP1

Cell Biology

SCYE1