Coxsackievirus and adenovirus receptor

E5123Hu

Sandwich

48T,96T

0.092ng/ml

0.2-60ng/ml

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.

40,030

1525

CAR;CAR4/6;Coxsackievirus and adenovirus receptor;Coxsackievirus B-adenovirus receptor;CVB3-binding protein;CXADR;HCAR;HCVADR

CXADR

Microbiology

CXADR