E3 ubiquitin-protein ligase TRIM63

E5218Hu

Sandwich

48T,96T

3.13ng/L

7-1500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

E3 ubiquitin-protein ligase TRIM63, also known as "MuRF1", is an enzyme that in humans is encoded by the TRIM63 gene. This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.

40,248

84676

E3 ubiquitin-protein ligase TRIM63;IRF;Iris RING finger protein;MURF1;MuRF-1;MURF2;Muscle-specific RING finger protein 1;RING finger protein 28;RING-type E3 ubiquitin transferase TRIM63;RNF28;SMRZ;Striated muscle RING zinc finger protein;TRIM63;Tripartite motif-containing protein 63

TRIM63

Cell Biology

TRIM63