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Home > Product > ELISA Kit > Human IgG Receptor Fcrn Large Subunit P51, FCGRT ELISA Kit

Human IgG Receptor Fcrn Large Subunit P51, FCGRT ELISA Kit

Human IgG Receptor Fcrn Large Subunit P51, FCGRT ELISA Kit

Product Summary

Size: 48T,96T

Sensitivity: 5.09ng/L

Detection range: 10-2000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product Summary

Size: 48T,96T

Sensitivity: 5.09ng/L

Detection range: 10-2000ng/L

Sample type: Serum, plasma, cell culture supernates

Reactive with: Human

Product overview

Full product name

IgG receptor FcRn large subunit p51

Code

E5450Hu

Assay type

Sandwich

Size

48T,96T

Sensitivity

5.09ng/L

Detection range

10-2000ng/L

Sample type

Serum, plasma, cell culture supernates

Species

Human

Storage

2-8ºC

Assay time

1h 30m

Background

Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:7964511, PubMed:10933786). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995). (Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29.

UniProt accession

MASS(Da)

39,743

GeneID

2217

Synonyms

alpha-chain;FCGRT;FCRN;IgG Fc fragment receptor transporter alpha chain;IgG receptor FcRn large subunit p51;Neonatal Fc receptor

Gene names

FCGRT

Research area

Others

Target protein

FCGRT

Components

Components Quantity
Pre-coated ELISA plate 12 * 8 well strips x1
Standard solution 0.5ml x1
Standard diluent 3ml x1
Streptavidin-HRP 6ml x1
Stop solution 6ml x1
Substrate solution A 6ml x1
Substrate solution B 6ml x1
Wash buffer concentrate (25x) 20ml x1
Biotinylated antibody 1ml x1

Protocol data

These standard curves of E5450Hu are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

Concentration O.D. Average Corrected
1280ng/L 2.147 2.296 2.244
2.446
640ng/L 1.421 1.396 1.344
1.372
320ng/L 0.822 0.769 0.717
0.717
160ng/L 0.503 0.526 0.474
0.549
80ng/L 0.268 0.29 0.238
0.312
0ng/L 0.047 0.052 0
0.057

Precision

We measured random samples of E5450Hu within the same batch/lot to ensure the consistency of the kits' performances.

Intra/Inter-Assay Sample n Mean Standard Deviation CV%
Intra-Assay 1 18 145.3 9.65 6.64
Intra-Assay 2 18 884.75 31.05 3.51
Intra-Assay 3 18 356.91 22.74 6.37

Protocols

References

Customer reviews and Q&As

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  • Size

    Code

    Price

  • 48T

    E5450Hu

    $320.00

  • 96T

    E5450Hu

    $458.00

Add to Cart

Lead time: Within two weeks

We are continuously updating our ELISA Kit catalog with advanced verified products. If you can not download the datasheet please send your request of our latest datasheet.

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