Interleukin-36 receptor antagonist protein

E5527Hu

Sandwich

48T,96T

1.35ng/L

3-900ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.

16,962

26525

FIL1;FIL1 delta;FIL1(DELTA);FIL1D;IL-1 delta;IL1F5;IL-1F5;IL1HY1;IL-1HY1;IL1L1;IL-1L1;IL-1ra homolog 1;IL-1-related protein 3;IL-1RP3;IL36RA;IL-36Ra;Interleukin-1 delta;Interleukin-1 family member 5;Interleukin-1 HY1;Interleukin-1 receptor antagonist homolog 1;Interleukin-1-like protein 1;Interleukin-36 receptor antagonist protein;PSORP;PSORS14

IL36RN

Immunology

IL1F5