Lactosylceramide 4-alpha-galactosyltransferase

E5550Hu

Sandwich

48T,96T

7.66ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Catalyzes the transfer of galactose from UDP-alpha-D-galactose to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)) (PubMed:10748143). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). Globoside Gb3Cer is a glycosphingolipid of the globo serie, one of the major types of neutral root structures of glycosphingolipids, that constitute a significant portion of mammalian cell membranes (Probable). Globotriaosylceramide/globoside Gb3Cer in blood and tissue cell membranes is the antigen Pk of blood histogroup P (PubMed:10747952). (Microbial infection) Globotriaosylceramide is one of the cellular ligands for bacterial verotoxins.

40,499

53947

A14GALT;A4GALT;Alpha-1,4-galactosyltransferase;Alpha-1,4-N-acetylglucosaminyltransferase;Alpha4Gal-T1;CD77 Synthase;Gb3 Synthase;Gb3S;Globotriaosylceramide Synthase;Lactosylceramide 4-alpha-galactosyltransferase;P(k);P1;P1/Pk Synthase;P1PK;PK;UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase

A4GALT

Cardiovascular

A4GALT