Protein HEXIM1

E5980Hu

Sandwich

48T,96T

9.61ng/L

20-4500ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869). May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

40,623

10614

Cardiac lineage protein 1;CLP1;EDG1;Estrogen down-regulated gene 1 protein;Hexamethylene bis-acetamide-inducible protein 1;HEXIM1;HIS1;MAQ1;Menage a quatre protein 1;Protein HEXIM1

HEXIM1

Epigenetics and Nuclear Signaling

HEXIM1