Sulfotransferase 1A1

E6231Hu

Sandwich

48T,96T

7.65ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621).

34,165

6817

Aryl sulfotransferase 1;HAST1/HAST2;Phenol sulfotransferase 1;Phenol-sulfating phenol sulfotransferase 1;P-PST;P-PST 1;PST;ST1A1;ST1A3;STP;STP1;Sulfotransferase 1A1;SULT1A1;Thermostable phenol sulfotransferase;ts-PST

SULT1A1

Others

SULT1A1