Transmembrane Channel-like protein 1

E6310Hu

Sandwich

48T,96T

7.43ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Transmembrane channel-like protein 1 is a protein that in humans is encoded by the TMC1 gene. TMC1 contains six transmembrane domains with both the C and N termini on the endoplasmic side of the membrane, as well as a large loop between domains 4 and 5. This topology is similar to that of transient receptor potential channels (TRPs), a family of proteins involved in the perception of senses such as temperature, taste, pressure, and vision. TMC1 has been located in the post-natal mouse cochlea, and knockouts for TMC1 and TMC2 result in both auditory and vestibular deficits (hearing loss and balance issues) indicating TMC1 is a molecular part of auditory transduction.

87,768

117531

DFNA36;DFNB11;DFNB7;TMC1;Transmembrane Channel-like protein 1;Transmembrane cochlear-expressed protein 1

TMC1

Neuroscience

TMC1