Ubiquitin-like modifier-activating enzyme ATG7

E6379Hu

Sandwich

48T,96T

5.18ng/L

10-2000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity).

77,960

10533

APG7L;APG7-LIKE;ATG12-activating enzyme E1 ATG7;ATG7;Autophagy-related protein 7;GSA7;hAGP7;SCAR31;Ubiquitin-activating enzyme E1-like protein;Ubiquitin-like modifier-activating enzyme ATG7

ATG7

Cell Biology; Neuroscience; Cancer; Cardiovascular; Metabolism

ATG7