Ubiquitin-like protein ATG12

E6380Hu

Sandwich

48T,96T

7.62ng/L

15-3000ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection (PubMed:17709747). Required for the translation of incoming hepatitis C virus (HCV) RNA and, thereby, for the initiation of HCV replication, but not required once infection is established (PubMed:19666601).

15,113

9140

APG12;APG12L;APG12-like;ATG12;Autophagy-related protein 12;FBR93;HAPG12;Ubiquitin-like protein ATG12

ATG12

Cell Biology

ATG12