NADH-ubiquinone oxidoreductase 75 kDa subunit

E6754Hu

Sandwich

48T,96T

11.11ng/L

20-3800ng/L

Serum, plasma, cell culture supernates

Human

2-8ºC

1h 30m

NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1) is an enzyme that in humans is encoded by the NDUFS1 gene. The encoded protein, NDUFS1, is the largest subunit of complex I, located on the inner mitochondrial membrane, and is important for mitochondrial oxidative phosphorylation. Mutations in this gene are associated with complex I deficiency. The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This protein is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized.

79,468

4719

CI-75k;CI-75Kd;Complex I-75kD;MC1DN5;NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial;NDUFS1;PRO1304

NDUFS1

Tags & Cell Markers; Neuroscience; Cancer; Metabolism

NDUFS1